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National antiretroviral treatment guidelines

Department of Health.
Introduction: South Africa?’s response to HIV and AIDS has evolved significantly over the last four to five years. Our response has been guided by our Strategic Plan for HIV and AIDS, 2000 ?– 2005, and the Comprehensive Plan for the Management, Care and Treatment of HIV and AIDS in South Africa.

Government?’s response to HIV covers the full range of interventions including:

  • Information, education and communication;
  • Prevention programmes, including access to barrier methods such as male and female condoms;
  • Increased access to voluntary counselling and testing;
  • Prevention of mother to child transmission of HIV;
  • Robust nutritional interventions; and
  • An emphasis on individual choice of treatment.


  • In order to ensure optimal therapy and good clinical outcomes, the Ministry and Department have developed these national guidelines for use of ART. These guidelines complement all other existing guidelines.

    Patients who are on ART need to comply with their treatment schedules. To facilitate this, counselling and family support, as well as robust nutritional interventions, are critical. Health care providers and clinicians in the public and private sector are encouraged to familiarise themselves with the content of these guidelines. This will ensure that we provide safe, sustainable and effective care to all our citizens.

    These guidelines will be subject to ongoing review in line with emerging evidence, as well as the information gathered from surveillance and pharmacovigilance monitoring.

    Partnerships with the private sector and civil society are critical for the successful implementation of these guidelines.

    This critical resource can be downloaded on the righthand side of this page.
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