Therapeutics Research on AIDS-Associated Opportunistic Infections and Malignancies: NIH

Abstract: The purpose of this program announcement is to encourage research grant applications aimed at novel approaches to discovery and preclinical development of therapeutic agents against opportunistic infections and malignancies in people with AIDS. The intent of this PA is to seek investigator-initiated grant applications that involve creative and original preclinical research utilizing state-of-the-art technologies necessary to propel advances in new or improved therapies. No clinical trials will be supported under this PA.

The goal of this PA is the development of agents for treatment of AIDS-associated opportunistic infections and malignancies. Given present advances in molecular biology, the principal objectives of the PA are to stimulate original and innovative preclinical research to identify and characterize new, pathogen-specific or malignancy-specific molecular targets, and develop promising therapeutic approaches. Applications directly linking disease pathogenesis to molecular target identification are encouraged.

AIDS-associated opportunistic pathogens emphasized by this PA are Mycobacterium tuberculosis, Pneumocystis carinii, Cryptosporidium parvum, and the microsporidia.

AIDS-associated malignancies emphasized by this PA are Kaposi's sarcoma, lymphomas, cervical cancer, oral warts and cancers, and anogenital cancers.

Sponsor: Department of Health and Human Services (DHHS), National Institutes of Health (NIH)

Ref No: PA-01-113

Deadline: September 01, 2002; January 02, 2003; May 01, 2003

Eligibility: Academic Institution or Government or Nonprofit

Contact details:

Kenneth Cremer, Ph.D., Division of Cancer Biology, NCI, Room 5016, 6130 Executive Boulevard, MSC 7398, Bethesda, Maryland, 20892-7398
Tel: +1 (301) 496-6085 Fax: +1 (301) 496-2025
e-mail: [email protected]

Dennis F. Mangan, Ph.D., Division of Extramural Research, NIDCR, Building 45, Room 4AN-32F, MSC 6402, Bethesda, Maryland, 20892-6402
Tel: +1 (301) 594-2421 Fax: +1 (301) 480-8318
e-mail: [email protected].

Chris Lambros, Ph.D. , Contact Address: Division of AIDS, National Institute of Allergy and Infectious Diseases, 6700-B Rockledge Drive, Room 5227, MSC 7624, Bethesda, Maryland
20892-7624, USA
Tel: +1 (301) 435-3769 Fax: +1 (301) 402-3171
e-mail: [email protected]